Diabetes is a major risk factor for the development of cad with a higher incidence of mi in patients with dm than those without55,56. Preterax and diamicron modifiedrelease controlled evaluation y vadt veterans affairs diabetes trial. Listing a study does not mean it has been evaluated by the u. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. Vadt randomly assigned 1791 veterans from 20 veterans affairs va medical centres who had type 2 diabetes. Persistent effects of intensive glycemic control on retinopathy in type 2 diabetes in the action to control cardiovascular risk in diabetes accord followon study.
A comparison of the effect of a targeted, intensified, multifactorial intervention with that of conventional treatment on risk factors for. Original article from the new england journal of medicine glucose control and vascular complications in veterans with type 2 diabetes. The diabetes control and complications trialepidemiology of diabetes interventions and complications dcctedic. Action to control cardiovascular risk in diabetes accord. The diabetes control and com plications trial research group. Type 2 diabetes significantly increases the risk of cardiovascular disease increased risk xfold stroke2,3 24 transient ischemic attack1 26 coronary heart disease3 2 coronary death3,4 23 nonfatal myocardial infarction3 2 heart failure1 23 peripheral vascular disease1 lowerlimb amputation 1540 intermittent claudication 39 overall, people with diabetes are 24 times more likely.
The diabetes control and complications trial dcct, published in 1993, showed that intensive glycaemic control i. People with diabetes have two to three times the risk of cvd than those without diabetes. Oct 10, 2015 diabetes is a major risk factor for the development of cad with a higher incidence of mi in patients with dm than those without55,56. In that large randomized clinical trial, funded by the va cooperative studies program and known as the va diabetes trial vadt, investigators tried to determine whether intensive levels of glucose control were. Glucose control and vascular complications in veterans with type 2 diabetes. In vadt, investigators randomized 1791 military veterans with diabetes, mean age 60 years, who had a suboptimal response to medical therapy to. Risk in diabetes, advance action in diabetes and vascular disease. Glucose control and vascular complications in veterans.
Estudios advance, accord, vadt, ukpds, dcct, steno. In particular, there is evidence of benefit of singlefactor interventions. Multifactorial interventions and cardiovascular disease in patients with type 2 diabetes. In addition, following a mi, diabetic patients have higher rates of morbidity, mortality and reinfarction than nondiabetics, with oneyear mortality rates of nearly 50%. Actualizacion en medicamentos antidiabeticos y riesgo cardiovascular. Diabetes is a metabolic disorder primarily characterized by elevated blood glucose levels and by microvascular and cardiovascular complications that substantially increase the morbidity and mortality associated with the disease and reduce the quality of life. Half the participants were allocated to tight control target blood pressure less than 15085 mm hg and were randomised to either atenolol or captopril, with other agents added as necessary.
The veterans affairs diabetes trial vadt was a randomised, prospective, multicentre study in. Intensive blood glucose control and vascular outcomes in. Empagliflozin, cardiovascular outcomes, and mortality in type. Gaude p, vedel p, larsen n, jensen gvh, parving h, pedersen o. Background in patients with type 2 diabetes, the effects of intensive glucose control on vascular outcomes remain uncertain. The new england journal of medicine n engl j med 360. Backgroundthe effects of empagliflozin, an inhibitor of sodiumglucose cotransporter 2, in addition to standard care, on cardiovascular morbidity and mortality in patients with type 2 diabetes. Type 1 diabetes is characterized by total reliance on exogenous insulin for survival and comprises. In january 2009, a team of va researchers published a study in the new england journal of medicine titled glucose control and vascular complications in veterans with type 2 diabetes.
Action to control cardiovascular risk in diabetes followon accordion eye study group and the action to control cardiovascular risk in diabetes followon accordion study group. Glucose control and vascular complications in veterans with. Implications of the united kingdom prospective diabetes study. In vadt, investigators randomized 1791 military veterans with diabetes, mean age 60 years, who had a suboptimal response to medical therapy to intensive glucose control or standard glucose control. Action to control cardiovascular risk in diabetes accord accord the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Mar 15, 1999 hypertension in diabetes study 18, 19one thousand one hundred and fortyeight patients took part.
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